FAQ瓦博
AWARENESS AND TRUST
Is Warburg Metabolically Targeted Cancer Immunotherapy an "alternative" form of cancer treatment?
No, it is not. The "alternative" cancer treatment space is filled with quackery and pseudo-science.
Warburg cancer therapy is based upon Nobel Prize-winning actual science, and is being practiced at scale at some of the finest hospitals in China.
· Two of Warburg's inventors, Dr Tom Tsang and Dr Linda Meade-Tollin hold PhD's — Tsang in Cancer Biology and Immunology, and Meade-Tollin in Biochemistry.
· Both Dr Tsang and Dr Meade-Tollin taught medical science at the University of Arizona, and held important positions at the Arizona Cancer Center.
· Warburg therapy utilizes some of the oldest and best documented chemotherapy drugs that have proven wide applicability and effectiveness.
· Warburg therapy has had the safety of its protocols validated in a peer-reviewed article in Cancer Medicine (2024).
· Warburg therapy has had its pain relief effects validated in a peer reviewed article in the Journal of Pain Research (2026).
Warburg Metabolically Targeted Cancer Immunotherapy is, simply, not "alt" — it is a rock-solid, mainstream-science based, immunotherapy method that uses insulin and proven chemotherapy drugs in an innovative way that preserves and enhances immune system function to create better outcomes for patients.
Is Warburg Metabolically Targeted Cancer Immunotherapy "experimental" cancer therapy?
Yes, it is considered experimental in Western nations, but it is important to understand what the word experimental means in this context.
By definition, any form of medical treatment not included in official clinical treatment guidelines is experimental. The Warburg method protocols are not included in any Western guidelines we are aware of and are, therefore, deemed experimental in those countries.
As a practical matter, Warburg therapy is not "experimental" in China, and it is being widely used to treat patients today.
Warburg cancer therapy is practiced at over 30 medical facilities in China — including some of the finest and most advanced hospitals in China.
We have treated over 10,000 patients using Warburg methods in China since 2021, and our network of hospitals and licensed Chinese physicians employing Warburg protocols has expanded continuously over the past 6 years.
To give the Warburg China scope of practice and patient numbers context —
Western patients have come to us with Stage III or Stage IV cancer after conventional chemotherapy and / or immunotherapy is failing, or has failed. Some have tried, and failed, to qualify for an experimental clinical trial in the United States or other Western nations.
Experimental trials of drugs or methods / protocols in Western countries very rarely exceed 500 participants. Much more commonly, clinical trials are in the range of 300, 200, or even less than 200 patients.
The clinical trial is being conducted precisely because there are too few data points to form a scientific, evidence-based, opinion about the efficacy of the method — hence, "experimental".
In that context, Warburg cancer therapy isn't experimental at all.
There are all sorts of cancer treatment claims online. How can I judge if the Warburg Metabolically Targeted Immunotherapy method is scientifically sound?
It is completely correct for you to have vigilance when evaluating medical claims, whether found online or elsewhere. Here are five questions we suggest you use to evaluate cancer treatment claims and methods, along with brief Warburg China answers to them:
Q: Is the suggested method conducted in a regular medical institution?
A: Warburg China conducts treatments at the Shanghai Xiehua Brain Hospital, a flagship facility of the Asia-Pacific Medical Group. Located within the New Hongqiao International Medical Park, this 300 bed 170 million dollar hospital opened in 2024.
SXBH serves both local residents and non-Chinese patients, and provides medical services including neurosurgery, neurology, cardiology, gastroenterology, respiratory medicine, radiological medicine, orthopedics, and general surgery.
Q: Is there a professional medical team monitoring the entire process?
A: Each Warburg China treatment is closely monitored by Shanghai Xiehua Brain Hospital doctors and staff, as well as a Warburg China provided translator / nurse.
During the treatment process, blood glucose, blood pressure, and heart rate are continuously electronically monitored, giving the attending physicians and staff real-time data about the patients metabolic status and well being.
SXBH is one of the best staffed hospitals in China. Its prestigious reputation has allowed it to employ some of the finest medical professionals in China, many of whom speak English. The diverse, state of the art, medical capabilities of SXBH ensure that advanced medical support of all types is immediately available — within the hospital — during treatment, should it be required.
The Warburg China translator / nurse is present not only during treatment to ensure seamless communication, but meets the patient at the start of the day at the hotel, is present throughout the treatment, and accompanies them back to the hotel after the patient has recovered.
Q: Have peer-reviewed papers been published about the method?
A: Warburg method therapy has two peer-reviewed published papers —
· A safety study published in Cancer Medicine (2024) that illuminates why we have never lost a patient during treatment.
· A confirmation of what we have long-observed — rapid and substantial pain relief without using narcotics — published in the Journal of Pain Research (2026).
Q: Are there clear explanations of indications and contraindications?
A: Some alleged cancer treatment "protocols" — especially those found online — are "one size fits all", and those who promote them suggest that they have found the "magic bullet" that "cures" cancer.
Warburg China evaluates potential patients on a case by case basis and, while it is always sad, we are not unwilling to tell potential patients that they do not qualify for, or will not benefit from, Warburg method immunotherapy.
Q: Who invented the method? Do they have real scientific credentials?
A: Warburg Metabolically Targeted Cancer Immunotherapy was invented by Dr Tom Tsang, Dr Linda Mead-Tollin and Michael Pennington.
· Cumulatively, they are authors or co-authors of over 70 peer-reviewed medical papers addressing various aspects of cancer science that have been published in prestigious journals such as Cancer Research, Cancer Medicine, British Journal of Cancer, Oncogenes and the Journal of Pain Research.
· Dr Tom Tsang, Dr Linda Meade-Tollin and Michael Pennington are named inventors
on Warburg Method patents that have been granted by many countries.
· All three held important senior positions at the Arizona Cancer Center, and have
been cancer scientists their entire adult lives.
· Both Dr Tom Tsang and Dr Linda Meade-Tollin held professorships at the University of Arizona, teaching cancer science and medicine.
· Dr Tom Tsang and Dr Linda Meade-Tollin presented the Warburg methodology at
the Society of Integrative Oncology (SIO) International Conference held in Scottsdale, Arizona, in 2018.
· Dr Tom Tsang and Dr Linda Meade-Tollin presented the Warburg methodology at
the American Association for Cancer Research (AACR) annual meeting in 2020.
· Dr Tom Tsang is currently a senior cancer scientist and professor at Chongqing University — one of China's premier medical research institutions.
Tom, Linda and Michael have been joined by a broad array of physicians and cancer researchers, worldwide, who have contributed to the development and refinement of the protocols practiced by Warburg China today.
In the "About" section of this website we offer biographies of Dr Tom Tsang, Dr Linda Meade-Tollin and Michael Pennington, as well as a partial list of Valued Colleagues and Hospitals who have participated in the development and implementation of the Warburg cancer treatment protocols.
Why haven't I heard of Warburg therapy being used in major hospitals in my country? Why didn't my doctor recommend it?
Most people think of "guidelines" as suggestions. Within Western medical communities, treatment guidelines are much more like tripwires for excommunication.
Guidelines serve legitimate purposes — medicine certainly requires "standard" protocols to guide physicians — but rigid guidelines have a fundamental weakness: the latency between new science and treatment implementation.
For those facing life-threatening disease, this is a massive problem. For that patient, idea that maybe, at some undetermined point in the future, this or that method might find its way into the guidelines and actually become widely available is nothing more than a receding mirage that the patient will never live to see become a sanctioned therapy they might be able to get.
As a practical matter, Western hospitals, medical standards bodies and medical communities, particularly in the United States but in many other countries as well, effectively ban treatment outside conventional guidelines.
To briefly quote Dr Tom Tsang from his longer answers to these questions —
"In the United States, but also in many other Western countries, practicing protocols outside those sanctioned by particular medical standards bodies makes the physician effectively uninsurable, and in some cases could lead to license revocation. These impediments, along with fear of reputational harm for treating patients outside conventional Western medical guidelines, has severely limited the availability of Warburg Therapy for patients in Western nations."
For those who would like to read a longer response to these questions, please read "Why isn't Warburg therapy more widely used?" and Dr Tsang's companion notes "Why can't I get Warburg treatments in my country?".
We are deeply grateful to the Chinese government for its belief in Warburg Metabolically Targeted Cancer Immunotherapy, and the opportunity it has given us to practice it at scale, demonstrate its efficacy, and help our patients today.
It is our most cherished hope that our example will inspire medical communities, worldwide, to fairly and rapidly consider our cancer treatment methods, integrate them into their practices, and thereby save patients lives using them.
My oncologist tells me that entering a hypoglycemic state is very dangerous. Is that true?
It is certainly true that entering an unplanned and unmonitored hypoglycemic state is dangerous — but that has nothing to do with how Warburg method cancer immunotherapy is practiced in China, or what Warburg method patients experience during a treatment.
Warburg China patients being treated at Shanghai Xiehua Brain Hospital are continuously monitored throughout each Warburg procedure using three methods:
· High tech machine monitoring which provides the hospital's medical staff with precise real-time data as to the patient's blood sugar levels and other vital signs.
· Frequent, traditional, pin-prick blood withdrawals which are immediately analyzed to provide a second source of information to confirm the blood sugar readings being provided by the machine monitoring.
· Ongoing conversation with the patient by hospital staff throughout the procedure to confirm that the patient is comfortable, and not experiencing any sensation that might indicate a problem.
Throughout the entire Warburg China treatment process, a wide array of vital signs
are also continuously electronically monitored.
Should any of these monitoring methods show the slightest deviation from expected — optimal — values, the treatment is aborted, and normal blood sugar levels restored, usually in about one minute. Aborted treatments are very rare.
· Warburg method cancer therapy was found to be safe by a peer-review safety study published in Cancer Medicine (2024) that reviewed 8,542 treatments.
· Warburg China has never lost a patient due to the effects of hypoglycemia.
FAQ瓦博
PRINCIPLES AND EFFECTIVENESS
What is Warburg Metabolically Targeted Cancer Immunotherapy all about? Can you explain how it works in just a few paragraphs?
Cancer cells require more sugar than healthy cells.
Cancer cells ferment sugar into lactic acid to generate energy, whereas normal cells "burn" sugar with oxygen. Fermentation is a very inefficient way to harvest energy — given the exact same amount of sugar, normal cells generate 18 times more energy than cancer cells.
Warburg Metabolically Targeted Cancer Immunotherapy uses insulin to lower blood sugar, causing cancer cells to experience "sugar deprivation".
Sugar deprivation cuts off the power supply to the cancer cell's "multidrug-resistant protein pumps" which they use to expel, and thereby render ineffective, chemotherapy drugs.
With the multidrug-resistant protein pumps shut down, a small dose of chemotherapy is enough to kill the cancer cell.
As or more importantly, the lactic acid produced by cancer cells when metabolizing sugar "masks" the cancer from the immune system.
Lowering blood sugar breaks this defensive mechanism by shutting down lactic acid production, which enables the immune system to "see" and kill cancer cells rapidly — an effect that operates in parallel with the direct cancer-killing effects of chemotherapy.
The Warburg therapeutic approach pairs exceptionally well with other immune-targeted therapies and cellular therapies because altering the micro-environment within the cancer cell is the foundation of all immunotherapy.
Don't cancer cells naturally love sugar? Who doesn't know that?
Many people know that cancer cells love sugar, but very few take the next step: cancer cells love sugar not just to grow larger and multiply faster, but to power their "multidrug-resistant protein pumps".
What Warburg therapy does is take a metabolic process that others merely acknowledge, understand that process as a fundamental weakness of the cancer cell, and actively exploit that weakness to treat the disease.
Moreover, this sugar-loving trait is not unique to a specific type of cancer — it is a feature common to almost all cancers, with higher malignancy correlating with higher sugar consumption.
This near-universal metabolic characteristic of cancer cells makes our method widely applicable across a very broad spectrum of cancers.
Can Warburg therapy cure my cancer?
We do not make exaggerated promises. We do not claim this is a "cure for cancer". We are not focused on challenging clinical guidelines outside China, and we do not argue over right and wrong.
Warburg China is focused on one thing: patient outcomes.
· If by "cure" you mean "cleared the patients body of detectable cancer using modern diagnostic methods", the answer is yes, Warburg China has achieved that outcome with some patients, as have other cancer treatment methods.
· If by "cure" you mean "cleared the patients body of detectable cancer using modern diagnostic methods, and cancer never reoccurred", the answer is unclear: Warburg has treated patients who remained cancer-free until they died, many years later, of other causes. This result, too, has been achieved by other treatment methods.
All we claim is that Warburg cancer therapy offers unique advantages in overcoming drug resistance, shrinking tumors, relieving cancer pain, and protecting immune system function and vigor.
Specific outcomes vary from person to person: many patients experience rapid tumor shrinkage, many experience a drop in tumor markers.
Warburg therapy is particularly well-suited for elderly patients, as those over 70 typically cannot tolerate traditional high-dose chemotherapy.
We suggest that if your cancer has metastasized and conventional treatments are no longer working, Warburg method immunotherapy offers a proven approach that can address the challenges you are facing, and spare you many of the debilitating effects of conventional cancer treatment alternatives.
Is the pain-relief effect really that good?
Yes. A peer reviewed study published in the Journal of Pain Research in 2026 showed an 80% effectiveness rate for pain relief.
Traditional morphine merely masks pain, treating the symptom rather than the root cause. Warburg method cancer therapy directly targets and kills cancer cells, shrinks tumors, and eliminates pain from the source.
Most Warburg China patients experience pain reduction during their first treatment cycle.
FAQ瓦博
SAFETY AND SIDE EFFECTS
Will hypoglycemia be fatal? I am very worried about this.
Warburg China places patient safety first, and has never lost a patient due to the effects of the hypoglycemic treatment protocol.
Our treatment protocols employ multiple diagnostic tools to inform our doctors, nurses, and support staff of the patient's condition at all times during treatment.
· Electronic blood sugar monitors provide the hospital's medical staff with precise real-time data as to the patient's blood sugar levels and vital signs.
· Frequent, traditional, pin-prick blood analysis provides a second source of information about blood sugar levels to confirm the information being provided by the machine monitoring.
· Ongoing conversation with the patient by hospital staff throughout the procedure provides a third source of information to confirm that the patient is comfortable, and not experiencing any sensation that might indicate a problem.
Throughout the entire Warburg China treatment process, a wide array of vital signs are also continuously electronically monitored.
Should any of these monitoring methods show the slightest deviation from expected — optimal — values, the treatment is aborted, and normal blood sugar levels restored, usually in about one minute.
Aborted treatments are very rare, and a peer reviewed study published in Cancer Medicine in 2024 documents 8,542 treatments that confirm the safety of the Warburg China treatment protocols.
Will I lose my hair? Are nausea and vomiting severe?
Generally, hair loss does not occur, and nausea and vomiting are very mild. Because the Warburg individual chemotherapy drug dosage is only about one-tenth of conventional levels, the terrifying side effects of traditional chemotherapy are drastically minimized.
My body is already very weak. Can I handle Warburg treatments?
Warburg therapy is not suitable for every cancer patient — Warburg China doctors must make a comprehensive judgment based on your physical condition, tumor type, blood sugar levels, treatment history and more.
For those who are suitable, precisely because the individual chemo dosage is small and of short duration, Warburg treatments have minimal impact on normal cells, and much less impact on the normal functioning of the body.
In the simplest terms, the body is far less stressed by Warburg therapy compared to high-dose conventional chemotherapy, which is a distinct quality of life advantage, particularly for elderly individuals with weaker bodies and weak recovery capabilities.
I have diabetes. Can I still have Warburg treatments?
The majority of diabetic patients can have Warburg treatments. We have treated many diabetic patients: as long as insulin can bring blood sugar down, there are generally no issues. However, patients with severe diabetes or poorly controlled blood glucose require a detailed evaluation prior to beginning treatment.
FAQ瓦博
THE TREATMENT EXPERIENCE
Do Warburg treatments hurt?
There is no pain throughout the entire process. It is simply an intravenous infusion; you might experience mild sweating or heart palpitations — which are transient feelings of hypoglycemia that quickly disappear once blood sugar recovers.
How long does a single Warburg treatment take?
Each infusion takes about 90 minutes, followed by roughly 3 hours of monitoring in the hospital.
What is a treatment "cycle", and how many will I need?
Unlike conventional chemotherapy — which delivers a single debilitating Maximum Tolerated Dosage payload — Warburg method cancer therapy delivers roughly the same cumulative payload divided into smaller doses over a number of days, which constitutes a Warburg treatment "cycle".
· A treatment cycle usually consists of 10 consecutive treatment days.
· The minimum rest period before starting another cycle is typically 10 to 20 days.
· Most patients require 2-3 cycles of treatment, with 2 being most common.
· Longer than minimum spacing of cycles is not uncommon, and is frequently deemed medically desirable.
Can I eat during the treatment?
You must fast starting the night before treatment (for at least 7 hours). You cannot eat food or drink sugary water on your own during the treatment. You must eat at designated times according to the doctor's instructions. You will be promptly fed after the treatment concludes to restore your blood sugar.
Do I need to be hospitalized?
Warburg treatments can be done on an outpatient basis or via hospitalization, depending on your condition.
The vast majority of Warburg China treatments are performed outpatient, with the patient returning to the Hilton Shanghai Hongqiao each day after treatment.
FAQ瓦博
APPLICABILITY
Can my type of cancer be treated with Warburg Metabolically Targeted Cancer Immunotherapy?
Warburg therapy has proven effective on a wide variety of advanced solid tumors, including stomach cancer, colorectal cancer, head and neck tumors, lung cancer (including small cell lung cancer), breast cancer, gynecological tumors, lymphoma, and sarcoma, among others.
The key is not the cancer type, but whether the tumor "lights up" with high sugar uptake on a PET-CT scan — tumors with high glucose uptake usually respond better.
I already have widespread metastasis. Can Warburg still be useful?
Yes — your problem is one of the Warburg method's greatest strengths.
For patients experiencing recurrence and metastasis where conventional treatments are ineffective, this therapy provides a new direction and choice.
I am already resistant to chemotherapy and have tried multiple regimens to no avail. Is Warburg a viable option for me?
Yes — this is precisely the problem Warburg therapy addresses most effectively.
The core of chemo resistance is drug-resistant protein pumps pushing the drugs out of the cancer cell. We first "cut the power" to stop these pumps, allowing previously ineffective chemotherapy drugs to potentially become effective again.
The chemo component of Warburg therapy is not about finding a new drug, but making old drugs work again.
I was just diagnosed and haven't started chemotherapy yet. Should I start Warburg treatments immediately?
In earlier stages of cancer's expression, it is generally recommended that patients be treated with Warburg therapy in combination with standard anti-tumor treatments. A doctor's evaluation is required to see if Warburg method therapy is applicable to your emergent cancer.
· We hope that this FAQ has provided you with information that illuminates the scientific underpinnings of Warburg Metabolically Targeted Immunotherapy, and the scale at which it is being used to treat patients in China today.
· We are available to answer any questions you may have, and welcome the opportunity to do so.
· Our suggestion is this: if you are interested in Warburg therapy and would like to learn more about its possible applicability to your situation, contact us.
· We routinely review the medical records of non-Chinese cancer sufferers who are considering being treated by Warburg China in Shanghai, and appreciate any documentation you can provide our medical team as we begin this conversation.
· We also welcome contact from your existing cancer treatment doctors and other medical professionals.
· If you would prefer to begin the conversation without providing medical records, please simply email us and describe your situation; what additional information you may require; and how you would like us to help.
WHY ISN'T THE WARBURG
METHOD MORE WIDELY USED?
Conventional people are roused to fury by departure from convention,
largely because they regard such departure
as a criticism of themselves
Bertrand Russell
Most people don't think of scientific inquiries as having fashions, but they do.
According to one myth, the March Of Science is a linear process, with each advance building logically on immediately previous discoveries.
In reality, science more closely resembles a long and winding road, with many dead-end detours that are only recognized when you get to the end of the cul-de-sac.
The importance of Warburg's work was well understood in his lifetime — the Nobel Prize and multitude of other awards he received attest to that — but the development of usable metabolic treatment protocols was derailed by the mid 20th century scientific steamroller that was genetic science.
The discovery of the double-helix structure of DNA in 1953 by Francis Crick and James Watson was a momentous breakthrough. Their work, along with that of Rosalind Franklin and Maurice Wilkins, laid the foundation for what we now know about the human genome.
By the 1960s and 70s the focus of cancer research had shifted from metabolic biochemical process models to genetics, as scientists increasingly viewed cancer as a disease governed by mutated genes. Genetics was hailed as a window on the origins of cancer and, it was thought, a path to new treatment methods, or even a path to a cure.
As the century progressed, the biochemical metabolic processes that Warburg identified and quantified were increasingly sidelined.
By the latter part of the 20th century important chemical processes within cancer cells, including those associated with Multidrug-resistant Protein Pumps, began to be referred to as "housekeeping" activities — necessary cellular mechanisms, but largely irrelevant to understanding the origins of cancer and, most importantly from a cancer sufferers perspective, to the development of useful treatment strategies and protocols.
Unfortunately, this pivot to genetics has not resulted in widely applicable treatment methods, and many cancer scientists have come to feel that the hard pivot to genetics as a path to treatment and cure was a mistake.
These skeptical scientists included the late James Watson himself. Interviewed by Sam Apple of the New York Times in 2016 — sixty-three years after the discovery of the double helix of DNA — Watson stated that locating the genes that cause cancer had been "remarkably unhelpful" and that "if he were going into cancer research today...he would study biochemistry rather than molecular biology".
The 21st century has brought renewed interest, worldwide, in Warburg and its biochemical approach to cancer treatment, but decades of neglect has also created regulatory hurdles that prevent patients from getting Warburg treatments, particularly in Western countries.
WHY CAN'T I GET
WARBURG TREATMENTS
IN MY COUNTRY?
BY DR TOM TSANG
In fact, you might be able to get Warburg therapy in your home country — if you can find a doctor willing to to perform the treatments, and an appropriate medical setting to have them performed.
· My co-inventors, Dr Linda Meade-Tollin and Michael Pennington, and I, have always held the easing of cancer pain and the eradication of cancer as our highest values — and have always been transparent about our therapeutic methods and protocols.
· My co-inventors and I hold international medical and biological patents related to Warburg, and have never filed for any patent that would restrict the ability of any health care organization to employ Warburg therapy methods and protocols.
· Along with my co-inventors, I actively encourage physicians, worldwide, to consider the benefits to their patients of Warburg therapy, and employ it.
· My co-inventors and I clearly state: every physician and medical organization, worldwide, is free to use our work and incorporate Warburg therapy as part of its cancer treatment protocols free of charge, or any other obligation to us.
The reality of getting treated using Warburg protocols in Western countries is, unfortunately, more complicated than this blanket permission. In the United States, but also in many other Western countries, practicing protocols outside those sanctioned by particular medical standards bodies makes the physician effectively uninsurable, and in some cases could lead to license revocation.
These impediments, along with fear of reputational harm for treating patients outside conventional Western medical guidelines, has severely limited the availability of Warburg Therapy for patients in Western nations.
Albert Einstein wrote, "Out of clutter, find simplicity".
We believe that, while well-meaning, Western cancer research has, to a great extent, become a clutter of data substantially divorced from from patient outcomes in the present moment.
Our method is fundamentally simple, broadly applicable, and singularly focused on one thing: enabling the best possible outcomes for patients suffering from cancer, today.
Warburg China is deeply grateful to the People's Republic of China for its belief in our methodology, and for entrusting us with the well-being of its citizens.
That belief and generous support has given us the opportunity to treat over 10,000 patients in the past 5 years who were suffering from a wide range of cancers; demonstrate the efficacy of the method at scale; and create a reproducible therapeutic blueprint that we know will benefit cancer patients, worldwide.
Most importantly, it has been a great honor and privilege to help our patients, whether Chinese or Western, to free themselves from pain, and embrace their futures with greater hope.
For those who know the foundations of traditional Chinese medicine, the modern adoption of Warburg Therapy in China is not surprising.
Traditional Chinese medical practice places patient safety and quality of life first, so protocols like the "maximum tolerated dose" of Western chemotherapy are inherently viewed with suspicion by both physicians and patients.
As a result of that suspicion, a large segment of the Chinese population prefer to exercise their freedom to choose treatment paths that are less debilitating, and that many believe may be more efficacious.
If you are a cancer sufferer interested in Warburg Therapy and are not able, or do not choose, to be treated by Warburg China in Shanghai, we encourage you to explore with your health care provider whether Warburg Therapy might be available to you where you live, and how you might benefit.
Dr Tom Tsang
Senior Cancer Scientist
Warburg 瓦博 China
Shanghai, People's Republic of China
October, 2026
ABOUT WARBURG
Modern Warburg Metabolically Targeted Cancer Immunotherapy builds upon the work of Dr Otto Warburg, a 20th century German biochemist and physiologist. Warburg was nominated for the Nobel Prize in Medicine 47 times, and won it in 1931.
His work in the latter 1920's focused on the metabolic processes within cancer cells, specifically their method for harvesting energy and how that process could be manipulated using insulin.
His discoveries about cancer cell metabolism are the foundation for the PET-CT scan, universally acknowledged as the most accurate cancer imaging diagnostic technology available today, as well as much of our current understanding of the biochemical processes within cancer cells.
The method combines Warburg's metabolic discoveries with a fundamental inversion of the cancer chemotherapy dosing paradigm: insulin-enabled dosing protocols which are designed to preserve the immune system and enable it to respond vigorously to cancer wherever it may be found in the body.
Warburg China's metabolically targeted cancer immunotherapy method is based upon the work of Dr Tom Tsang, Dr Linda Meade-Tollin and Michael Pennington of the University of Arizona, co-inventors of our protocols.
DR TOM TSANG
SENIOR CANCER SCIENTIST, CO-INVENTOR
Born in Taiwan in 1964, Dr Tom Tsang's entire adult life has been devoted to understanding cancer and, more importantly, designing practical treatment protocols to fight it.
Tom and his brother and sister were born in Taipei, Taiwan, where Tom's father was a manager at a large bank affiliated with the city.
Tom's family migrated to the United States in 1976 when his mother, a pediatric nurse, was recruited by Children's Hospital at Erlanger in Chattanooga, Tennessee. After a brief subsequent stay in Santa Barbara, California, the family settled in Tucson where Tom attended Junior High and High School, and went on to study at the University of Arizona.
Tom earned two degrees from the University of Arizona: a bachelors in biochemistry and a PhD in Cancer Biology and Immunology in 1994.
His thesis advisor and first mentor was the legendary Dr Tim Bowden, then Chief Scientific Officer of the Arizona Cancer Center, and Tom formed a friendship and professional collaboration with him that lasted throughout Bowden's lifetime.
Tom's doctoral studies were punctuated by a real-world battle with cancer that was a watershed moment in his thinking, and which has defined his entire career: his aunt's breast cancer, which presented itself just as he was finalizing his doctoral dissertation.
Living in Taiwan, Chuntao Chen reached out to her nephew to ask if there were any advanced American cancer therapies that might help her. She included detailed information about the course of treatment that the Taiwanese oncologists were recommending, a regimen consisting of surgery and conventional chemotherapy.
Tom shared the information widely among top physicians at the Arizona Cancer Center and was dismayed to find that, despite the supposedly advanced ideas circulating at ACC, there was consensus among the physicians that what the Taiwanese oncologists were recommending was precisely what they would recommend — because the proposed treatment strategy was consistent with conventional guidelines which were, apparently, unquestioned whether in Taipei or Tucson.
This news was a blow, not only because Tom was unable to provide useful ideas regarding his aunt's specific problem, but because it highlighted a fundamental question he had begun to have about his career path, and about what value cancer research had if it was decoupled from useful therapeutic methodologies.
The question that persistently plagued him was blindingly simple: what is knowledge good for if it doesn't result in real-world implementations?
Tom's PhD dissertation is dedicated to Chuntao Chen, and his focus on turning scientific facts into treatment methodology has been unwavering his entire career.
It was also while studying for his PhD and working in Tim Bowden's lab that Tom met Dr Linda Meade-Tollin, a renowned biochemist and professor of biochemistry with whom he has collaborated for over 30 years.
Linda's area of greatest expertise is cancer metastasis, and she was working with the lab and running experiments using their equipment and facilities.
Beyond simply really liking her, Tom was impressed with the questions she asked in lab meetings, unusually fundamental questions like "what does this data mean?"
It may seem strange to note a question about "meaning" in the context of data harvested for a scientific inquiry, but Tom was beginning to believe that Western cancer science had focused far to much on narrow datasets accumulated primarily for publication, and far too little on understanding fundamental cancer cell architecture and biochemical mechanisms that would lead to useful treatment protocols.
In Dr Meade-Tollin he felt that he had found not only a teacher and mentor, but a kindred spirit.
After Tom was awarded his doctorate, he accepted a position as a cancer investigator at the Arizona Cancer Center, an institution which became his home until moving to China in 2009.
He and Linda continued their mutual search for widely applicable treatment methodologies, and as their collaboration deepened, Tom came to value not only Linda's scientific insights, but her courage in staying focused on large, hard, questions — the answers to which they both felt held the keys to practical cancer treatment protocols.
It was at one of countless lunch meetings that Linda introduced Tom to the work of Otto Warburg, specifically Warburg's 1927 paper that outlined the effects of insulin on the metabolic processes within cancerous cells.
The heart of that paper is the quantification of the biochemical effects of glucose deprivation on cancer cells — the "Warburg Effect" — that doctors Tsang and Meade-Tollin have spent the past more than three decades weaponizing to destroy cancerous tumors.
Short-term glucose deprivation using insulin was Warburg's observational tool — alone, it does very little to harm cancer cells: they do not "starve" in the common meaning of that word, as some believe.
Rather, as Tom and Linda came to understand, the metabolic changes that occur within cancer cells during the window of time that the cancer cell is glucose deprived open a world of therapeutic possibilities when combined with well-proven chemotherapy drugs and the robust response of an undamaged immune system.
Of particular interest to Tom and Linda was their belief that — if appropriate treatment protocols could be developed — metabolically targeting cancer using insulin could be used to save patients now, not at some ever-receding future date.
They also understood that by attacking cancer cells using metabolic processes that are common to all types of cancers, the resulting treatment method would be applicable to virtually all types of cancer, regardless of origin, type, or metastasized location within the body.
In this quest for effective treatment method and cure they were soon joined by Michael Pennington, the third co-inventor of the modern Warburg protocols that are practiced by Warburg China today.
While ancestry perhaps played a part, Tom did not migrate to China out of ancestral longing. Rather — and despite his very harmonious tenure at the Arizona Cancer Center — as time progressed he had become increasingly frustrated by the Western prioritization of cancer research over cancer treatment.
In Tom's view, the obsessive focus on publication in Western medical circles had to a great degree made research an end in itself, rather than a gateway to protocols that could be immediately implemented to treat cancer patients now.
In the early 2000s Tom received the support of the American Goodwill Mission to China, and he began to travel to China frequently, and for increasingly longer trips.
These trips revealed a far greater willingness on the part of Chinese physicians and patients to consider the benefits of Warburg Therapy — notably more than he and his co-inventors had experienced in the United States.
As or more importantly, he found great interest in the method on the part of the Chinese government, which under the Chinese system means that many of the impediments that new medical methodologies face in the West simply do not exist in China.
In 2009 Tom moved to China, and it is not an exaggeration to say that China is the true birthplace of modern Warburg Metabolically Targeted Cancer Immunotherapy.
Generous support from the government of the People's Republic of China — which has demonstrated unwavering belief in Warburg methodology — has enabled the testing and refinement of treatment protocols at a scale, and speed, that is not possible in the West, where crossed wires of regulation, professional timidity and the constant threat of potential legal entanglements chronically stifle medical innovation.
For over 15 years Tom has trained medical providers throughout China, and served as a liaison between patients and providers at over 30 medical facilities that have treated over 10,000 cancer patients since 2021 using Warburg China protocols.
Tom is currently a senior cancer scientist at Chongqing University — one of China's premier medical research institutions — located in Chongqing, China, and regularly commutes to the premier Warburg treatment facility for non-Chinese patients, Shanghai Xiehua Brain Hospital, located in Shanghai.
He lives with his wife and daughters in Zhangjiagang, about 80 miles inland from Shanghai, and typically takes the "slow" train running the route — a mere 185 mph — when going to the hospital, because he says it gives him a couple of extra minutes to think.
DR LINDA MEADE-TOLLIN
BIOCHEMIST, CO-INVENTOR
Linda grew up in London, West Virginia, and comes from a gifted and accomplished family.
Her father, Robert Meade, a 1920s graduate of Howard University, was a well-known dentist; a violinist with the Charleston Symphony Orchestra; and was for many years President of the local NAACP chapter where he was instrumental in advancing integration efforts that were beginning to transform West Virginia society in the 1950s and 1960s.
Her mother, Virginia, was an educator who held a Bachelors degree from West Virginia State College, and a Masters from Columbia University in New York City.
Recognized as exceptionally intelligent from a very early age, Linda skipped two grades before graduating High School.
At her mother's wish, she stayed close to home after graduation, enrolling at Virginia's alma mater, West Virginia State College, in the Fall of 1960 at age 16.
Majoring in chemistry, Linda received a Bachelor of Science degree, cum laude, from WVSC in 1964.
Moving to New York after graduation she worked in the diagnostic labs of both Harlem and Bellevue hospitals, major New York health care providers where she learned important lessons about the discipline and precision required in biochemistry, and witnessed the power of medicine to save and transform lives.
Linda went on to obtain a Master of Arts degree in biochemistry from Hunter College in New York in 1969, and was the first African-American woman to receive a PhD in biochemistry from City University of New York, granted in 1972.
All of this was accomplished before age 28.
In 1975 Linda accepted a National Institutes of Health biochemistry postdoctoral research fellowship at the University of Arizona in Tucson, an institution that she called home for nearly 35 years.
It was at the University of Arizona that Dr Meade-Tollin met Tom Tsang when she was a post-doc doing research in the Arizona Cancer Center's lab under the Chief Scientific officer, Dr Tim Bowden, and Tom was in a doctoral program and working in the lab to gain practical bio-med experience.
He was, she says, "a very unusual person", and even at a young age a "visionary" who was able to merge disparate ideas into larger concepts that provided testable approaches to solve difficult questions.
She also recognized that they shared a temperamental and intellectual disdain for the traditional post-doctoral career path that often did not lead to better patient outcomes.
Both found themselves outsiders within the bio-medical community; both believed in the common humanity of people from different cultures; and both shared a disdain for the elevation of publication — no matter how trivial the subject matter — over the integration of scientific facts that would enable practical cancer treatment methods and protocols.
Their unbroken friendship and collaboration has endure for over 35 years, and the current Warburg Method is substantially a product of it.
In addition to her scientific accomplishments, Linda has been a mentor to countless students, and an unwavering advocate for under-represented groups in the sciences.
Among a multitude of other leadership roles, for a number of years she was the director of the University of Arizona Office of Women in Science and Engineering, and in 1993 became the first female chair of the executive board of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE).
She is also the recipient of the prestigious Henry Hill Award for Research from NOBCChE, which recognizes persons with outstanding achievements in the chemical sciences, and she has an endowed chemistry department scholarship in her name at West Virginia State College.
Linda retired from the University of Arizona as a Research Professor Emerita in 2008. She continues her life's work to cure cancer, and has continued to publish work with Tom Tsang and others that furthers awareness of how Warburg Therapy can benefit patients — and how it can be implemented today.
MICHAEL PENNINGTON
CO-INVENTOR
Dr Tom Tsang often introduces Michael Pennington as being a person "who knows more about cancer than I do", and consistently cites three invaluable contributions he made to the development of the modern Warburg protocols that are practiced by Warburg China today.
· Michael was the first to recognize a simple but foundational fact: conventional immunotherapy, which is usually combined with conventional chemotherapy, is a fundamentally flawed therapeutic concept. The flaw lies in the fact that conventional chemotherapy largely destroys immune system function, so the two methods — chemotherapy and immunotherapy — when combined using standard guidelines, are working at cross-purposes.
· Michael was the first to hypothesize that glucose deprivation using insulin would inactivate the cancer cell's Multidrug-resistant Protein Pumps. This metabolic process is the core mechanism that allows Warburg to use Minimum Effective Dose chemotherapy payloads that preserve the health and vitality of the immune system, and that spares patients the debilitating effects of Maximum Tolerated Dose chemo protocols.
· Michael worked closely with Tom to develop the current Warburg Therapy Standard Protocol that uses Fluorouracil and Cyclophosphamide. This fundamental choice of widely available and widely applicable chemotherapy drugs has proven highly effective, and made the Warburg Method straightforward to replicate in a broad range of treatment settings. In addition, these drugs broad applicability has largely decoupled Warburg Therapy from the need to have an oncologist review and supervise each individual case, making the method available to more patients on a more timely basis.
Michael's introduction to cancer research was when he was the head technician in the laboratory of Dr Anne Cress at the University of Arizona Cancer Center. His responsibilities included training graduate students and post-docs in the techniques and analytic methodology used in the lab.
As fate would have it, one of those graduate students was Tom Tsang, and Dr Linda Meade-Tollin's office was just down the hall.
It is Tom Tsang's belief that much of the credit for the discoveries and therapeutic insights that emerged from the Arizona Cancer Center lab are directly attributable to Michael Pennington — a belief that Linda Meade-Tollin strongly shares.
COLLEAGUES & HOSPITALS
Dr Tom Tsang, Dr Linda Meade-Tollin and Michael Pennington wish to acknowledge the contributions of many other colleagues, worldwide, who have contributed to our efforts, and the hard work of the vast number of medical professionals and hospitals throughout China who have so expertly transformed our ideas into real-world therapy for patients, at scale.
A very partial list of our valued associates and participating hospitals appears below. For members of the Warburg family not named — please know that we appreciate and value your expertise and professionalism, and are deeply grateful that you have joined us on this journey.
411 Hospital 医院 Shanghai
Richard Ablin, PhD (1940-2023)
Ron Adams
Emmanuel Akporiaye, PhD
Saad Alowi
American Goodwill Mission To China, Inc.
Kaya Andrews, PhD
Christen Anfinsen, PhD
Bruce Ash
Michael Badowski, PhD
David Baltimore (1938-2025), PhD
Ron Barber, Congressman from Arizona
Keith Bonham, PhD
Diane Bowden
Tim Bowden (1944-2018), PhD
Jianhua Cao 曹建华 MD
Tom Cech, PhD
Deyu Chen 陈德玉 MD, PhD
Jingren Chen 陈敬仁 MD
Zhao Chen, PhD
Yi-Wen Chu, PhD
Ken Cook
Anne Cress, PhD
John D'Andrea
Connie Daih
Pascal Dammeyer, PhD
Chris Deufield, PhD
Kate Dixon, PhD
Carmen Dolny, JD
Sally Drachman
Mike Figuroa, JD
Joanne Finch
Xiaona Gao 高小娜 MD
Donato Perez Garcia III, MD
Martha Gonzalez
Michael Graham, MD
Fang Guo 郭方 MD, PhD
Ashok Gupta, MD, PhD
David Harris, PhD
Humphrey He, MD, PhD
Mary Hendrix, PhD
Evan Hersh, MD
Dan Von Hoff, MD
Doris and Tom Hoffman
Karen Holliday, MD
Emily and Jen Hopkins
Deborah Jeffe, PhD
Jianjia Hospital 健嘉医院 Foshan
Rein Kilkson (1927-2011), PhD
James Kolbe (1942-2022), Congressman from Arizona
Jason Konnor, MD
Benjamin Lagarda and Family
Kit Lam, MD, PhD
Clifton Leaf
Ron Lehman, JD
Suyi Li 李苏宜 MD, PhD
Yun Lin
Yang Ling 凌扬 MD, PhD
Hanju Liu 刘汉举 MD
Jiliang Liu 刘积良 MD
Phoebe Liu, PhD
Sheldon Liu, MD
Yongping Liu 刘永萍 MD, PhD
Peihua Lu 陆培华 MD, PhD
John Marchalonis, PhD
Jesse Martinez, PhD
Gavin Milczarek-Desai, PhD
Alberto Moore
Rich Moret
Mike Munday
Mark O'Hare, JD
Andres D. Onate (1940-2025), PhD
Larry Ostrowski, PhD
Jialing Pao-Tao, PhD
Linus Pauling (1901-1994), PhD
Shuxin Peng 彭书新 MD
Brian Pipes
Jesus Antonio Pujol, Congressman from Sonora, Mexico
Zijian Qi 戚自建 MD
Qiande Hospital 乾德医院 Nanjing
Zhongling Ren 任中林 MD
Renhua Hospital 仁华医院 Wuxi
Keith Rosenblum
Valerie Rulick
Brandt Schneider, PhD
John C. Scott
Michael Shaller, PhD
Shanghai Xiehua Brain Hospital 上海协华脑科医院 Shanghai
Bingyin Shi 施秉银 MD
Wenhai Shi 施文海 MD
Shoukang Hospital 首康医院 Shengzhen
Yanice and Gary Smith
Alison Stopek, MD
Siwei Su 粟四维 PhD
Sabina and Tom Sullivan
Weijun Sun 孙卫军 MD
Isaac Tao 陶遂 MD
Sylvia Tidwell-Scheuring
Jeff Utsch
Tony Vuturoy, MD
Wanan Hospital 万安医院 Luohe
Weifeng Wang 王卫峰 MD
Andrew Weil, MD
Wende Hospital 文德医院 Luoyang
Merell and David Whitney
Yuqing Xiang 向玉琴 MD
Jinpeng Xie 谢晋鹏 MD
Xiji Hospital 西机医院 Baoji
Xuchao Xue 薛绪潮 MD, PhD
Douglas Yamanishi, PhD
Yiling Hospital 以峰医院 Shijiazhuang
Beibei Zhao 赵蓓蓓 MD
Zhongwu Hospital 钟吾医院 Xuzhou